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Join Us

Research Scientist: Assay Development (Technical Development Team)
Location: Hatfield, PA 
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In this role you will be a part of our dynamic Technical Development (TD) team focused on non-viral therapies using our novel DNA scaffold technology. This will require you to develop biophysical and chromatography assays and perform characterization studies on our 3DNA scaffolds and constructs. You will partner with our internal R&D team and external collaborators to design, develop and qualify assays to measure critical quality attributes of our products and intermediates.

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Responsibilities

  • Work independently and as part of an interdisciplinary team to develop assays, characterize process intermediates and test conjugated drug substances based on the company’s novel DNA scaffold technology.

  • Develop chromatography and biophysical assays to accurately determine size, structure, polydispersity and purity of our intermediates and therapeutic candidates.

  • Characterize targeting and payload molecules including peptides, proteins, and oligonucleotide conjugates.

  • Work with R&D team and development partners to adapt and refine various assays to support phase-appropriate technical development studies.

  • Maintain data records and analysis in electronic laboratory notebook and perform data analysis including basic statistics to evaluate method performance.

  • Draft method development reports, test method SOPs and characterization reports.

  • Maintain laboratory equipment and perform limited troubleshooting as needed.

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Education and Experience 

  • BS in Biochemistry, Chemistry, Biology, or equivalent degree with a minimum of 5 years of assay development experience in a pharmaceutical industry setting, or an MS with a minimum of 2 years of industry experience; PhD in Biochemistry, Chemistry, Biology, or equivalent degree with demonstrated biochemical/biophysical assay development experience preferred

  • Demonstrated experience with HPLC assay development

  • Familiarity with the characterization of macromolecules by mass spectrometry, including but not limited to LC-MS and ESI

  • In-depth understanding of biophysical assays such as dynamic light scattering, field flow fractionation, SEC-MALLS, and AUC

  • Familiarity with nucleic acids isolation and sample preparation (DNA, RNA, etc.)

  • Sound writing and documentation skills. Ability to perform data analysis using Excel, Minitab or JMP

  • Well-versed in ICH guidelines such as Analytical Validation (Q2), Analytical Procedure Development (Q14), Stability (Q1A), etc.

  • Detail-oriented with strong organizational and communication skills

  • Ability to work independently and multitask in a highly entrepreneurial environment

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Skills, Abilities and Competencies

  • Familiarity with Six Sigma and Design of Experiments (DOE)

  • Method qualification and validation experience

  • Experience with PCR-based assay development, including but not limited to qPCR, digital PCR, endpoint PCR, and basic bioinformatics

  • Experience with biochemical and biophysical techniques including but not limited to ELISA, Biacore, Octet

  • Experience with chemical conjugation techniques

  • Experience with mammalian cell culture

  • Ability to work in parallel on multiple projects

  • Excellent communication skills

  • Self -motivated and independent minded

  • Positive interpersonal skills with the ability to interact with individuals from a variety of levels and functions

  • Responsive, can-do attitude

  • Ability to quickly adapt to rapidly changing environment and demands

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We offer a competitive salary and benefit package, including an employer matched 401k. Code Bio is proud to be an Equal Opportunity Employer.

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Interested individuals should send a cover letter and CV to careers@codebiotx.com or:

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