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Research Scientist: Gene Delivery
Location: Hatfield, PA
The research scientist is a key member of the Discovery Research Team and participates in the development of Code’s gene delivery platforms. S/he will be critical in the work we are doing to develop cell and molecular assays and to assess potency and durability of genetic payloads. S/he will be a key contributor to the team in research, design and execution of approaches to deliver gene editing payloads to both in vitro and in vivo.
Responsibilities
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Work independently and a part of an interdisciplinary team to evaluate non-viral gene therapies using our patented DNA scaffold technology.
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Develop cell and molecular assays to assess potency and durability of genetic payloads.
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Perform in vitro assays of gene expression including ELISA, microscopy, luciferase, SEAP, and other cell-based potency assays.
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Research, design, and execute approaches to deliver gene editing payloads to diverse cell types in vitro and in vivo.
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Collaborate and manage projects between industry, academia, and internal partners.
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Design and test protocols for transfer to the Development team.
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Maintain data acquisition and analysis in electronic laboratory notebook.
Education and Experience
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PhD in genetics, molecular biology, biochemistry or cell biology with 0-3 years of experience or a BS or MS with 5+ years of laboratory experience
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Detail-oriented with strong organizational and communication skills
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Ability to work independently and multitask in a highly entrepreneurial environment
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Hands-on experience with mammalian cell culture
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Transfection and transduction in cells
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Experience with standard molecular techniques: DNA/RNA isolation, quantitative PCR, Western blotting, fluorescence microscopy
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Experience with various plate-based assay screens (i.e., fluorescence, luminescence, and/or ELISA)
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Experience in molecular cloning and designing expression vectors
Skills, Abilities and Competencies
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Experience with non-viral vectors, AAV, and/or vaccine development
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Experience with gene editing field and techniques such as CRISPR
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Ability to design, coordinate, and interpret animal studies
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Flexible and comfortable with a fast-paced and evolving business environment
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Ability to work in parallel on multiple projects
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Excellent communication skills
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Self -motivated and independent minded
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Positive interpersonal skills with the ability to interact with individuals from a variety of levels and functions
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Responsive, can-do attitude
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Ability to quickly adapt to rapidly changing environment and demands
We offer a competitive salary and benefit package, including an employer matched 401k. Code Bio is proud to be an Equal Opportunity Employer.
Interested individuals should send a cover letter and CV to careers@codebiotx.com or: