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Join Us

Analytical Development Scientist (Technical Development)
Location: On-site (Hatfield, PA) 

In this role you will be a part of our dynamic Technical Development (TD) team focused on non-viral therapies using our novel DNA scaffold technology.  This will require you to develop a variety of chromatography and molecular biology assays and perform characterization studies on our 3DNA scaffolds and constructs.  You will partner with our internal R&D team and external collaborators to design, develop and qualify assays to measure critical quality attributes of our products and intermediates.


The primary responsibilities of this position include, but are not limited to:

  • Work independently and as part of an interdisciplinary team to develop assays, characterize process intermediates and test conjugated drug substances based on the company’s novel DNA scaffold technology.

  • Develop chromatography- and molecular biology-based assays to accurately determine purity, content, size, structure and function of our intermediates and therapeutic candidates.

  • Characterize targeting and payload molecules including peptides, proteins, and oligonucleotide conjugates.

  • Work with R&D team and development partners to adapt and refine various assays to support phase-appropriate technical development studies.

  • Maintain data records and analysis in ELN records and perform data analysis, including basic statistics, to evaluate method performance.

  • Draft method development reports, test method SOPs and characterization reports.

  • Maintain laboratory equipment and perform limited troubleshooting as needed.

Education and Experience 
  • BS in Biochemistry, Chemistry, Biology, or equivalent degree with a minimum of 5 years of assay development experience in a pharmaceutical industry setting, or an MS with a minimum of 2 years of industry experience

  • Demonstrated experience working with nucleic acids including, but not limited to:

  • PCR assay development: endpoint, quantitative, and digital format(s)

  • Plasmid DNA expression, purification, and restriction enzyme analysis

  • In vitro RNA transcription and quantification

  • Hybridization assay development

  • Demonstrated experience with HPLC assay development: RP-HPLC, SEC-HPLC, IEX, and/or other chromatography formats

  • Familiarity with ELISA assay development and troubleshooting

  • Familiarity with the characterization of macromolecular binding interactions by SPR, BLI, and/or ELISA

  • Sound writing and documentation skills. Ability to perform data analysis using Excel, Minitab or JMP

  • Well-versed in ICH guidelines such as Analytical Validation (Q2), Analytical Procedure Development (Q14), Stability (Q1A), etc.

  • Detail-oriented with strong organizational skills

  • Ability to work independently and multitask in a highly entrepreneurial environment

  • Flexible and comfortable with a fast-paced and evolving business environment

  • Excellent communication skills

  • Positive interpersonal skills with the ability to interact with individuals from a variety of levels and functions, leads by example

  • Responsive, can-do attitude

  •  Preferred Skills/Experience

    • PhD in Biochemistry, Chemistry, Biology, or equivalent degree with demonstrated biochemical/biophysical assay development experience

    • Demonstrated experience with the development of chromatography-based assays specific to nucleic acids analysis

    • Method qualification and validation experience

    • Experience with the purification of macromolecules by FPLC, e.g., Äkta Explorer/Avant

    • Experience with chemical conjugation techniques

    • Experience with mammalian cell culture

    • Familiarity with Six Sigma and Design of Experiments (DOE)


We offer a competitive salary and benefit package, including an employer matched 401k. Code Bio is proud to be an Equal Opportunity Employer.

Interested individuals should send a cover letter and CV to or:

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